Vitamin K

From NuGOwiki

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

Vitamin K
2D structure for Vitamin K
Chemical Name	2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
Chemical Formula	C₃₁H₄₆O₂
CAS Number	12001-79-5
Chemical Information	HMDB03555
Biochemical Taxonomy
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood
Tissue Location	Liver
Normal Biofluid Concentrations	Blood: 0.0058 (0.0020-0.017) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Women postmenopausal
Other (Monogenic Disorders)	Coumarin resistance OMIM: 122700 Rhizomelic chondrodysplasia punctata, type 1 OMIM: 215100 Vitamin k-dependent clotting factors, combined deficiency of, 1 OMIM: 277450 Vitamin k-dependent clotting factors, combined deficiency of, 2 OMIM: 607473
Abnormal Biofluid Concentrations	Blood (Women postmenopausal): 0.0011 +/- 0.0042 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: vitamin K 1 (vitamin K 1) derived from plants, vitamin K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, vitamin K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.( PubChem)

Vitamin K is a group name for a number of related compounds, which have in common a methylated naphthoquinone ring structure, and which vary in the aliphatic side chain attached at the 3-position (see figure 1). Phylloquinone (also known as vitamin K1) invariably contains in its side chain four isoprenoid residues, one of which is unsaturated. A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.