Pyroglutamic acid

From NuGOwiki

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

Pyroglutamic acid
2D structure for Pyroglutamic acid
Chemical Name	(2S)-5-oxopyrrolidine-2-carboxylic acid
Chemical Formula	C₅H₇NO₃
CAS Number	98-79-3
Chemical Information	HMDB00267
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Essential Amino Acid
Nutritional Taxonomy	Not Available
Metabolic Pathways	Glutathione Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Skin Brain
Normal Biofluid Concentrations	Blood: 19.5 +/- 3.7 umol/L Cerebrospinal Fluid (CSF): 41.0 +/- 31.0 uM Cerebrospinal Fluid (CSF): 47 +/- 30 uM Urine: 24.1 umol/mmol creatinine Urine: 3.1 umol/mmol creatinine Urine: 4.4 umol/mmol creatinine Urine: 5.3 umol/mmol creatinine Urine: 7.3 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Pyroglutamic aciduria
Other (Monogenic Disorders)	Glutathione synthetase deficiency OMIM: 266130
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Pyroglutamic aciduria): 2326.0 uM Urine (Pyroglutamic aciduria): 1.9 umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
A cyclized derivative of L-glutamic acid. Elevated blood levels may be associated with problems of glutamine or glutathione metabolism. This compound is found in substantial amounts in brain tissue and other tissue in bound form, esp. skin. Also present in plant tissues.