Oxoglutaric acid

From NuGOwiki

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

Oxoglutaric acid
2D structure for Oxoglutaric acid
Chemical Name	2-oxopentanedioic acid
Chemical Formula	C₅H₆O₅
CAS Number	328-50-7
Chemical Information	HMDB00208
Biochemical Taxonomy	Dicarboxylic Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Alanine and Aspartate Metabolism Glutathione Metabolism Glycine, Serine and Threonine Metabolism Lysine Degradation Pantothenate and CoA Biosynthesis Reductive Carboxylate Cycle (CO2 Fixation) Valine, Leucine and Isoleucine Biosynthesis Valine, Leucine and Isoleucine Degradation Vitamin B6 Metabolism
Biofluid Location	Blood Cellular Cytoplasm Cerebrospinal Fluid (CSF) Urine
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 20.7 +/- 2.5 uM Blood: 7.0 (0.0-23.0) uM Blood: 8.6 +/- 2.6 umol/L Blood: 8.9 +/- 2.7 uM Blood: 9.3 +/- 2.3 uM Cellular Cytoplasm: 320 (290-350) uM Cerebrospinal Fluid (CSF): 2.0 +/- 2.0 uM Cerebrospinal Fluid (CSF): 2.1 +/- 0.7 uM Cerebrospinal Fluid (CSF): 4.80 (3.40-6.20) uM Cerebrospinal Fluid (CSF): 5 +/- 4 uM Cerebrospinal Fluid (CSF): 8.9 +/- 3.4 uM Urine: 150.5 umol/mmol creatinine Urine: 2.87 (0.18-14.3) umol/mmol creatinine Urine: 2.98 (0.42-18.3) umol/mmol creatinine Urine: 21.4 umol/mmol creatinine Urine: 23.6 umol/mmol creatinine Urine: 236.9 umol/mmol creatinine Urine: 25.6 umol/mmol creatinine Urine: 38.2 umol/mmol creatinine Urine: <150 umol/mmol creatinine Urine: > 0.658 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Anoxia
Other (Monogenic Disorders)	Hyperoxaluria, primary, type I OMIM: 259900 Refsum disease OMIM: 266500
Abnormal Biofluid Concentrations	Cellular Cytoplasm (Anoxia): 150 (144-156) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
Alpha-ketoglutaric acid is an important biological compound and is a key intermediate in the Krebs cycle. Alpha-ketoglutaric acid occurs naturally within cells. One of its functions is to combine with ammonia to form glutamic acid and then glutamine. Another function is to combine with nitrogen released in the cell, therefore preventing nitrogen overload. (wikipedia)