Mevalonic acid

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Mevalonic acid
2D structure for Mevalonic acid
Chemical Name	3,5-dihydroxy-3-methyl-Pentanoic acid
Chemical Formula	C₆H₁₂O₄
CAS Number	150-97-0
Chemical Information	HMDB00227
Biochemical Taxonomy	Phospholipids
Functional Taxonomy	DNA Component
Nutritional Taxonomy	Not Available
Metabolic Pathways	Biosynthesis of Steroids
Biofluid Location	Blood Urine
Tissue Location	Liver Lymphocyte Fibroblasts
Normal Biofluid Concentrations	Blood: 0.028 +/- 0.006 uM Blood: 0.043 +/- 0.013 uM Urine: 0.0531 umol/mmol creatinine Urine: 0.178 (0.0515-0.545) umol/mmol creatinine Urine: 0.5 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Smith-Lemli-Opitz syndrome(SLOS)
Other (Monogenic Disorders)	Hyper-igd syndrome OMIM: 260920 Smith-lemli-opitz syndrome OMIM: 270400
Abnormal Biofluid Concentrations	Blood (Smith-Lemli-Opitz syndrome(SLOS)): 0.012 +/- 0.002 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Mevalonic acid is a key organic compound in biochemistry. It is a precursor in the biosynthetic pathway, known as the HMG-CoA reductase pathway, that produces terpenes and steroids. Mevalonate is produced by NADPH from 3-hydroxy-3-methylglutaryl CoA via reduction. This reaction occurs in the cytosol. It is the committed step in cholesterol synthesis, -- Wikipedia The production of mevalonic acid (MVA) by the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, is the rate-limiting step in the biosynthesis of cholesterol. (Jemal et. al, Rapid Communications in Mass Spectrometry, 2003, 17:1715) Plasma concentrations and urinary excretion of MVA are decreased by HMG-CoA reductase inhibitor drugs such as pravastatin, simvastatin and atorvastatin. Naoumova RP, Marais AD, Mountney J, Firth JC, Rendell NB, Taylor GW, Thompson GR. Atherosclerosis 1996; 119: 203.