From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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All Metabolites | Biochemical | Nutritional | Functional | Metabolic Pathways | Diseases | Phenotypes | Physiological Processes | Protein |
| Methionine | |
|---|---|
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| Chemical Name | 2-amino-4-methylsulfanyl-butanoic acid |
| Chemical Formula | C5H11NO2S |
| CAS Number | 63-68-3 |
| Chemical Information | HMDB00696 |
| Biochemical Taxonomy | |
| Functional Taxonomy | growth |
| Nutritional Taxonomy | |
| Metabolic Pathways | methionine metabolism |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | Urine: 0-4.079 umol/mmol creatinine 1.21 +/- 1.20 umol/mmol creatinine Plasma: 6.67 +/- 8.66 uM 28.4 uM (25th and 75th percentile: 24.2, 32.2, n = 59 adults) CSF: 4.07 uM (3.00-5.14 uM) |
| Normal Tissue Concentrations | 400 uM (380-420 uM) - concentrations from Hexamita inflata (Protozoon) |
| Diseases / Conditions Related to Nutrition | cancer |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | Urine: Combined DEF. of 5-deoxyadenosylcobalamin and Methylcobalamin (clbc, Clbd, Clbf): normal/decreased Glycine N-methyltransferase Deficiency: 3.289e+04-6.579e+04 umol/mmol creatinine Methylcobalamin Synthesis Deficiency (cbl E, cbl G): decreased Hypermethioninemia: 16.45-85.53 umol/mmol creatinine Homocystinuria due to defect of N(5,10)-methylene THF Deficiency: 0-1.184 umol/mmol creatinine Homocystinuria. Cystathionine Beta-synthase Deficiency: 9.868-131.6 umol/mmol creatinine Tyrosinemia I: increased Hypermethioninemia, Familial: 2.434-65.79 umol/mmol creatinine Hypermethioninemia, Familial: increased 184.87 +/- 409.10 umol/mmol creatinine CSF: Hypermethioninemia, Familial: increased |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
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Contents |
Introduction
guidelines
A sulfur containing essential nonpolar amino acid that is important in many body functions. It is a chelating agent for heavy metals.
Methionine and cysteine are the only sulfur-containing proteinogenic amino acids. The methionine derivative S-adenosyl methionine (SAM) serves as a methyl donor. Methionine plays a role in cysteine, carnitine and taurine synthesis by the transsulfuration pathway, lecithin production, the synthesis of phosphatidylcholine and other phospholipids. Improper conversion of methionine can lead to atherosclerosis.