Iodotyrosine

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Iodotyrosine
2D structure for Iodotyrosine
Chemical Name (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
Chemical Formula C9H10INO3
CAS Number 70-78-0
Chemical Information HMDB00021
Biochemical Taxonomy

  • Amino Acids

Functional Taxonomy Not Available
Nutritional Taxonomy Not Available
Metabolic Pathways

  • Tyrosine Metabolism

Biofluid Location

  • Blood

Tissue Location

  • Thyroid Gland

Normal Biofluid Concentrations

  • Blood: 0.00069 +/- 0.00020 umol/L

Normal Tissue Concentrations Not Available
Diseases / Conditions Related to Nutrition

  • Athyroic patients

Other (Monogenic Disorders)

Abnormal Biofluid Concentrations

  • Blood (Athyroic patients): 0.00032 +/- 0.00008 umol/L

Abnormal Tissue Concentrations Not Available
Physiological Processes Not Available
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Contents

Introduction

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An iodated derivative of L-tyrosine. This is an early precursor to L-thyroxine, one of the primary thyroid hormones. In the thyroid gland, iodide is trapped, transported, and concentrated in the follicular lumen for thyroid hormone synthesis. Before trapped iodide can react with tyrosine residues, it must be oxidized by thyroid peroxidase. Iodotyrosine is made from tyrosine via thyroid peroxidase and then further iodinated by this enzyme to make the di-iodo and tri-iodo variants. Two molecules of di-iodotyrosine combine to form T4, and one molecule of mono-iodotyrosine combines with one molecule of di-iodotyrosine to form T3.

Biological Function

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Catabolism

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Diseases / Conditions Related to Nutrition

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  • Athyroic patients

Other (Monogenic) Disorders

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Nutritional Information

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Drivers for biological variation

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Vulnerable groups

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