From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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All Metabolites | Biochemical | Nutritional | Functional | Metabolic Pathways | Diseases | Phenotypes | Physiological Processes | Protein |
| IL8 | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for IL8]] | |
| Chemical Name | |
| Chemical Formula | |
| CAS Number | |
| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Interleukin 8 may be of clinical relevance in psoriasis and rheumatoid arthritis. Elevated concentrations are observed in psoriatic scales and this may explain the high proliferation rate observed in these cells. It may also be a marker of different inflammatory processes and probably plays a role in the pathogenesis of chronic polyarthritis since excessive amounts of this factor are found in synovial fluids.
Biological Function
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation.
Recommended name:
Interleukin-8, IL-8
Alternative name(s):
C-X-C motif chemokine ligand 8, CXCL8
Monocyte-derived neutrophil chemotactic factor,MDNCF
T-cell chemotactic factor
Neutrophil-activating protein 1,NAP-1
Protein 3-10C
Granulocyte chemotactic protein 1,GCP-1
Monocyte-derived neutrophil-activating peptide, MONAP
Emoctakin
Cleaved into the following 7 chains:
1- Recommended name:
MDNCF-a
Alternative name(s):
IL8/NAP1 form I
GCP/IL-8 protein IV
2- Recommended name:
Interleukin-8
Alternative name(s):
IL-8(1-77)
MDNCF-b
IL8/NAP1 form II
GCP/IL-8 protein II
(Ala-IL-8)77
3- Recommended name:
IL-8(5-77)
4- Recommended name:
IL-8(6-77)
Alternative name(s):
Lymphocyte-derived neutrophil-activating factor, LYNAP
Neutrophil-activating factor, NAF
MDNCF-c
IL8/NAP1 form III
GCP/IL-8 protein I
(Ser-IL-8)72
5- Recommended name:
IL-8(7-77)
Alternative name(s):
IL8/NAP1 form IV
GCP/IL-8 protein V
6- Recommended name:
IL-8(8-77)
Alternative name(s):
IL8/NAP1 form V
GCP/IL-8 protein VI
7- Recommended name:
IL-8(9-77)
Alternative name(s):
IL8/NAP1 form VI
GCP/IL-8 protein III
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation