From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| IL7 | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for IL7]] | |
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| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Human Interleukin-7
Interleukin 7 stimulates the proliferation of pre-B and pro-B-cells without affecting their differentiation. It also selectively supports the maturation of megakaryocytes. In human peripheral monocytes, IL-7 induces the synthesis of some inflammatory mediators such as IL-1, IL-6 and. It also enhances the expression and secretion of IL-3 and GM-CSF in activated human T-cells. IL-7 down-regulates expression of TGF-beta in macrophages which has been suggested as an inhibitor of the antitumor immune response.
Human Interleukin-7
IL-7 stimulates the proliferation of pre-B and pro-B-cells without affecting their differentiation. The protein does not act on mature B-cells. IL-7 stimulates the proliferation of early and mature activated T-cells and this activity is synergized by suboptimal doses of IL-1. Thymocytes proliferate in response to IL-7 independently of three other known T-cell growth factors, IL-2, IL-4, and IL-7. In Rodent peripheral monocytes, IL-7 induces the synthesis of some inflammatory mediators such as IL-1 and IL-6. It also enhances the expression and secretion of IL-3 and GM-CSF in activated Rodent T-cells. IL-7 down-regulates expression of TGF-beta in macrophages which has been suggested as an inhibitor of the anti-tumor immune response.
Biological Function
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation