From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| IL6 | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for IL6]] | |
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| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Human Interleukin-6
Interleukin 6 is a cytokine released by leukocytes in response to a number of inciting stimuli. In addition to its role as an acute phase reactant and endogenous pyrogen, IL-6 is also involved in B-cell differentiation into plasma cells. IL- 6 is usually not detected in normal serum, plasma, CSF, or joint fluid. Elevated levels are observed in a variety of inflammatory processes, including infections (endotoxemia) and collagen vascular diseases. IL-6 is also elevated in alcoholic cirrhosis and chronic renal failure.
Rodent Interleukin-6
IL-6 is a cytokine released by leukocytes in response to a number of inciting stimuli. In addition to its role as an acute phase reactant and endogenous pyrogen, IL-6 is also involved in B-cell differentiation into plasma cells. IL- 6 is usually not detected in normal serum, plasma, CSF, or joint fluid. Elevated levels are observed in a variety of inflammatory processes, including infections and collagen vascular diseases. IL-6 is also elevated in alcoholic cirrhosis and chronic renal failure.
Biological Function
IL6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation