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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| IL3 | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for IL3]] | |
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| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Interleukin 3 (IL3) is produced mainly by T-cells following cell activation by antigens and mitogens, but also by keratinocytes, NK-cells, mast cells, endothelial cells, and monocytes. IL-3 is one of the priming factors for hematopoietic stem cells in vitro and in vivo that makes the cells responsive to later-acting factors such as Epo, GM-CSF and IL-6. IL-3 also induces the increased expression of receptors for colony stimulating factors. At pico- to nanomolar concentrations IL-3 is a chemoattractant for eosinophils and also influences the chemotactic behavior of these cells in response to other chemotactically active factors. IL3 induces the proliferation of mast cells and macrophages and causes the synthesis of histamines by mast cells and phagocytosis in macrophages.
Recommended name:
Interleukin-3, IL-3
Alternative name(s):
Multipotential colony-stimulating factor
Hematopoietic growth factor
P-cell-stimulating factor
Mast cell growth factor, MCGF
Biological Function
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.