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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| IL23 | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for IL23]] | |
| Chemical Name | |
| Chemical Formula | |
| CAS Number | |
| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Biological Function
Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.
IL23A
Recommended name:
Interleukin-23 subunit alpha, IL-23 subunit alpha, IL23A
Alternative name(s):
Interleukin-23 subunit p19, IL-23p19
IL12B
Recommended name:
Interleukin-12 subunit beta, IL-12B
Alternative name(s):
IL-12 subunit p40
Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40
NK cell stimulatory factor chain 2,NKSF2
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation
Vulnerable groups
Other resources
Links
IL23A
IL12B