IL2

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IL2
[[Image:{{{Image}}}\|thumb\|220px\|2D structure for IL2]]
Chemical Name
Chemical Formula
CAS Number
Chemical Information
Biochemical Taxonomy
Functional Taxonomy
Nutritional Taxonomy
Metabolic Pathways
Biofluid Location
Tissue Location
Normal Biofluid Concentrations
Normal Tissue Concentrations
Diseases / Conditions Related to Nutrition
Other (Monogenic Disorders)
Abnormal Biofluid Concentrations
Abnormal Tissue Concentrations
Physiological Processes

Authors:	L. Pellis
Affiliations:	TNO, the Netherlands

1 Introduction
2 Biological Function
3 Catabolism
4 Diseases / Conditions Related to Nutrition
- 4.1 Associated decreased protein/metabolite profile
- 4.2 Associated increased protein/metabolite profile
5 Other (Monogenic) Disorders
6 Nutritional Information
7 Drivers for biological variation
8 Vulnerable groups
9 Other resources
10 Links

Introduction

guidelines
Human Interleukin-2

Interleukin 2 is a central regulator of immune responses, and plays a pivotal role in anti-inflammatory reactions, in hematopoiesis and in tumor surveillance. It stimulates the synthesis of IFN-gamma in peripheral leukocytes and also induces the secretion of IL-1, TNF-alpha and TNF-beta. IL-2 displays significant anti-tumor activity for a variety of tumor cell types since it supports the proliferation and clonal expansion of T-cells that specifically attack certain tumor types. A number of diseases have been described to be associated with the aberrant expression of IL-2 or IL-2 receptors, including Hodgkin's disease, Graft-versus-Host reaction, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosis, type-1 diabetes, lepromatous leprosy, AIDS, immunodeficiency syndrome, severe burn traumas, and allogenic bone marrow transplantation.

Rodent Interleukin-2 IL-2 is a central regulator of immune responses, and plays a pivotal role in anti-inflammatory reactions, in hematopoiesis and in tumor surveillance. It stimulates the synthesis of IFN-gamma in peripheral leukocytes and also induces the secretion of IL-1, TNF-alpha and TNF-beta. IL-2 displays significant anti-tumor activity for a variety of tumor cell types since it supports the proliferation and clonal expansion of T-cells that specifically attack certain tumor types. A number of diseases have been described to be associated with the aberrant expression of IL-2 or IL-2 receptors, including Hodgkin's disease, Graft-versus-Host reaction, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosis, type-1 diabetes, lepromatous leprosy, AIDS, immunodeficiency syndrome, severe burn traumas, and allogenic bone marrow transplantation.

Biological Function

guidelines

IL2 is required for T-cell proliferation and other activities crucial to regulation of the immune response and can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.