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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| IL1a | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for IL1a]] | |
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| Nutritional Taxonomy | |
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| Diseases / Conditions Related to Nutrition | |
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| Abnormal Tissue Concentrations | |
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| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
A soluble factor produced by monocytes, macrophages, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. IL-1 consists of two distinct forms, IL-1 alpha and IL-1 beta which perform the same functions but are distinct proteins. Interleukin-1 alpha is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses. IL-1 is of clinical significance due to its activities as a stimulator of T-cells. Peripheral blood mononuclear cells of patients with aplastic anemia show markedly decreased IL-1 production. It has been shown that IL-1 also promotes wound healing. This activity is thought to involve effects on angiogenesis, the promotion of fibroblast proliferation, and the chemotactic activity on neutrophils. Since elevated amounts of IL-1 are found in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis, receptor antagonists may be of advantage. IL-1-alpha may be a pathogenetic factor in the complex processes leading to vascular occlusion and an important in situ indicator of and a potential participant in vascular injury. It is consistently present in all vessels with sclerotic histopathologic changes following aortocoronary bypass grafting of saphenous veins and internal mammary arteries.
Biological Function
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation