From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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All Metabolites | Biochemical | Nutritional | Functional | Metabolic Pathways | Diseases | Phenotypes | Physiological Processes | Protein |
| IL16 | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for IL16]] | |
| Chemical Name | |
| Chemical Formula | |
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| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Interleukin 16 was described originally as Lymphocyte chemoattractant factor (LCF), which acts as a chemoattractant for CD4 (+) T-cells, macrophages, and eosinophils. The protein is produced by lymphocytes, eosinophils, mast cells, and lung epithelium. Fibroblasts from several tissues can express IL-16. Very high levels are produced in response to IL-1-beta.
Biological Function
Stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation