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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| IL15 | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for IL15]] | |
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| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Some of the biological activities of Interleukin 15 resemble those of IL-2. IL-15 and IL-2 differ in their controls of expression and secretion, their range of target cells and their functional activities. IL-15 stimulates proliferation of the established T-cell line CTLL-2 as well as phytohemagglutinin-stimulated peripheral blood mononuclear cells. In addition, it is also able to induce generation of cytolytic cells and LAK cells activity in vitro.
Biological Function
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.