From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| IL13 | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for IL13]] | |
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| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
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| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Interleukin 13 is expressed in activated T-helper cells and T-cells expressing CD8. It down-modulates macrophage activity, reducing the production of pro-inflammatory cytokines (IL-1 , IL-6 , IL-8 , IL-10 , IL-12 ) and chemokines (MIP-1 , MCP ) in response to IFN-gamma or bacterial lypopolysaccharides. IL-13 enhances the production of the IL-1 receptor antagonist. It also decreases the production of nitric oxide by activated macrophages, leading to a decrease in parasiticidal activity.
Biological Function
IL13 inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis.
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation