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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| IL10 | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for IL10]] | |
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| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
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| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Human Interleukin 10
Interleukin 10 is produced by, and down-regulates the function of, Th1 and Th2 cells. In human monocytes, IFN-gamma and IL-10 antagonize each other's production and function and has been shown to be a physiologic antagonist of IL-12. Studies suggest that IL-10 indirectly suppresses tumor growth of certain tumors by inhibiting infiltration of macrophages which may provide tumor growth promoting activity. It has been detected in the sera of a subgroup of patients with active non-Hodgkin's lymphoma, and it appear to correlate with a poor survival in patients with intermediate or high-grade non-Hodgkin's lymphoma.
Rodent Interleukin 10
IL-10 is produced by, and down-regulates the function of Th1 and Th2 cells. In macrophages stimulated by bacterial lipopolysaccharides IL-10 inhibits the synthesis of IL-1, IL-6 and TNF-alpha by promoting, among other things, the degradation of cytokine mRNA. It also leads to an inhibition of antigen presentation. In Rodent monocytes IFN-gamma and IL-10 antagonize each other's production and function. IL-10 has been shown also to be a physiologic antagonist of IL-12. Studies suggest that IL-10 indirectly suppresses tumor growth of certain tumors by inhibiting infiltration of macrophages which may provide tumor growth promoting activity.
Biological Function
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation