Tetrahexosylceramide (d18:1/12:0)

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Tetrahexosylceramide (d18:1/12:0)
2D structure for Tetrahexosylceramide (d18:1/12:0)
Chemical Name	N-((2S,3R,E)-1-((2R,3R,4R,5S,6R)-5-((2S,3R,4R,5R,6R)-5-((2R,3R,4S,5S,6R)-4-((2S,3R,4R,5R,6R)-3-ethanamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3-hydroxyoctadec-4-en-2-yl)dodecanamide
Chemical Formula	C₅₆H₁₀₂N₂O₂₃
CAS Number	11034-93-8
Chemical Information	HMDB04958
Biochemical Taxonomy	Glycolipids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Aminosugars Metabolism
Biofluid Location	Blood
Tissue Location	Erythrocyte Fibroblasts Kidney Liver Nerve Cells Nerves Brain
Normal Biofluid Concentrations	Blood: 1.5 +/- 1.0 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Abetalipoproteinemia Hypobetalipoproteinemia
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Abetalipoproteinemia): 1.5 (1.0-2.2) uM Blood (Hypobetalipoproteinemia): 1.0 (1.0-1.1) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
A glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. Tetrahexosylceramide contains a tetrasaccharide moiety bound in glycosidic linkage to the hydroxyl group of ceramide as the polar head group. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside Gb4 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues.