Ceramide (d18:1/18:0)

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Ceramide (d18:1/18:0)
2D structure for Ceramide (d18:1/18:0)
Chemical Name	N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)octadecanamide
Chemical Formula	C₃₆H₇₁NO₃
CAS Number	104404-17-3
Chemical Information	HMDB04950
Biochemical Taxonomy	Not Available
Functional Taxonomy	Second Messenger
Nutritional Taxonomy	Lipids
Metabolic Pathways	Galactose Metabolism Glycerolipid Metabolism Glycerophospholipid Metabolism Glycosphingolipid Metabolism
Biofluid Location	Not Available
Tissue Location	Epidermis Fibroblasts Intestine Keratinocyte Kidney Liver Muscle Myelin Nerves Neuron Neurons Pancreas Placenta Platelet Skeletal Muscle Skin Spleen Stratum Corneum Testes Thyroid Gland Brain
Normal Biofluid Concentrations	Not Available
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis (PMID 25935) and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis (PMID 14998372). Is key in the biosynthesis of glycosphingolipids and gangliosides.