Ganglioside GM3 (d18:1/16:0)

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Ganglioside GM3 (d18:1/16:0)
2D structure for Ganglioside GM3 (d18:1/16:0)
Chemical Name	(2S,4S,5R)-5-ethanamido-2-((2S,3R,4S,5S,6R)-2-((2R,3S,4R,5R,6R)-6-((2S,3R,E)-2-hexadecanamido-3-hydroxyoctadec-4-enyloxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yloxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid
Chemical Formula	C₅₇H₁₀₄N₂O₂₁
CAS Number	54827-14-4
Chemical Information	HMDB04844
Biochemical Taxonomy	Glycolipids
Functional Taxonomy	Membrane Component
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood
Tissue Location	Brain Brain Primarily Fibroblasts Myelin Stratum Corneum Testis Adrenal Gland
Normal Biofluid Concentrations	Blood: 4.5 +/- 1.0 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Abetalipoproteinemia Hypobetalipoproteinemia
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Abetalipoproteinemia): 4.0 (3.0-5.2) uM Blood (Hypobetalipoproteinemia): 4.0 (4.3-4.5) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
A glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GM3 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues