Metanephrine

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Metanephrine
2D structure for Metanephrine
Chemical Name	4-(1-hydroxy-2-methylamino-ethyl)-2-methoxy-phenol
Chemical Formula	C₁₀H₁₅NO₃
CAS Number	5001-33-2
Chemical Information	HMDB04063
Biochemical Taxonomy	Catecholamines and Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Urine
Tissue Location	Adrenal Medulla Adrenal Gland
Normal Biofluid Concentrations	Blood: 0.0003 uM Blood: 0.0016 (0.00018-0.0025) uM Urine: 0.0011 +/- 0.00034 umol/mmol creatinine Urine: < 0.467 umol/mmol creatinine Urine: <0.145 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Pheochromocytoma tumors with high epinephrine concentration tumors with low epinephrine concentration
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Pheochromocytoma): 0.00054 +/- 0.002 uM Blood (tumors with high epinephrine concentration): 0.00113-0.0165 uM Blood (tumors with low epinephrine concentration): 0.00021-0.00061 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Metanephrine is a metabolite of epinephrine created by action of catechol O-methyltransferase on epinephrine. Technically it is a product of epinephrine O-methylation. It is a commonly occurring, pharmacologically and physiologically inactive metabolite of epinephrine. The measurement of plasma free metanephrines is considered to be the best tool in the diagnosis of pheochromocytoma, a rare kind of adrenal medullary neoplasm.

In adrenal chromaffin cells, leakage of norepinephrine and epinephrine from storage granules leads to substantial intracellular production of the O-methylated metabolite metanephrine. In fact, the adrenals constitute the single largest source out of any organ system including the liver for circulating metanephrine. In humans, about 93 percent of circulating metanephrine is derived from catecholamines metabolized within adrenal chromaffin cells. (PMID 15317907)