From NuGOwiki

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

All Metabolites | Biochemical | Nutritional | Functional | Metabolic Pathways | Diseases | Phenotypes | Physiological Processes | Protein

D-Ornithine
2D structure for D-Ornithine
Chemical Name	(2R)-2,5-diaminopentanoic acid
Chemical Formula	C5H12N2O2
CAS Number	348-66-3
Chemical Information	HMDB03374
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood
Tissue Location	Intestine Liver Muscle Skeletal Muscle Skin Spleen Fibroblasts
Normal Biofluid Concentrations	Blood: 89.0 +/- 28.0 umol/L
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Patients with short bowel syndrome
Other (Monogenic Disorders)	Argininemia OMIM: 207800 Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome OMIM: 238970 Lysinuric protein intolerance OMIM: 222700
Abnormal Biofluid Concentrations	Blood (Patients with short bowel syndrome): 62.0 +/- 28.0 umol/L
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Contents 1 Introduction 2 Biological Function 3 Catabolism 4 Diseases / Conditions Related to Nutrition 5 Other (Monogenic) Disorders 6 Nutritional Information 7 Drivers for biological variation 8 Vulnerable groups 9 Other resources 10 Links

Introduction

guidelines
An amino acid produced in the urea cycle by the splitting off of urea from arginine. Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen.

Biological Function

guidelines

Catabolism

guidelines

Diseases / Conditions Related to Nutrition

guidelines

• Patients with short bowel syndrome

Other (Monogenic) Disorders

guidelines

• Argininemia OMIM: 207800
• Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome OMIM: 238970
• Lysinuric protein intolerance OMIM: 222700

Nutritional Information

guidelines

Drivers for biological variation

guidelines
The levels of the two non-proteinogenic amino acids that participate in the hepatic urea synthesis are associated with glucose homeostasis, shown by Shaham et al (PubMed). These two amino acids(in plasma) decreased by 35 and 29% respectively in response to an oral glucose challenge test. The decreases in citrulline and ornithine may be associated with the reduction in gluconeogenesis and urea synthesis following glucose ingestion as gluconeogenesis from amino acids (primarily from alanine)supports 25-40% of the non-glygogen-derived hepatic glucose output after an overnight fast.

Vulnerable groups

guidelines

Other resources

guidelines

Links

guidelines