Dihydrotestosterone

From NuGOwiki

(Redirected from HMDB02961)

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

Dihydrotestosterone
2D structure for Dihydrotestosterone
Chemical Name	(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
Chemical Formula	C₁₉H₃₀O₂
CAS Number	521-18-6
Chemical Information	HMDB02961
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood
Tissue Location	Adrenal Cortex Adrenal Gland Fibroblasts Gonads Hair Muscle Myelin Neurons Prostate Skin Testes Testis Thyroid Gland Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.0054 +/- 0.0028 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Psychiatric patient
Other (Monogenic Disorders)	17-@beta hydroxysteroid dehydrogenase III deficiency OMIM: 264300 Smith-lemli-opitz syndrome OMIM: 270400
Abnormal Biofluid Concentrations	Blood (Psychiatric patient): 0.0054 +/- 0.0029 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
Dihydrotestosterone (DHT) (INN: androstanolone) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5-alpha-reductase by means of reducing the alpha 4,5 double-bond. Dihydrotestosterone belongs to the class of compounds called androgens, also commonly called androgenic hormones or testoids. DHT is thought to be approximately 30 times more potent than testosterone because of increased affinity to the androgen receptor. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.