5,10-Methylene-THF

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5,10-Methylene-THF
2D structure for 5,10-Methylene-THF
Chemical Name
Chemical Formula	C₂₀H₂₃N₇O₆
CAS Number	31690-11-6
Chemical Information	HMDB01533
Biochemical Taxonomy	Pterins
Functional Taxonomy	DNA Component
Nutritional Taxonomy	Not Available
Metabolic Pathways	Glyoxylate and Dicarboxylate Metabolism Lysine Degradation One Carbon Pool by Folate
Biofluid Location	Blood
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.01 (0.0-0.21) umol/L
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Homocystinuria due to deficiency of n(5,10)-methylenetetrahydrofolate OMIM: 236250 Neural tube defects, folate-sensitive OMIM: 601634
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
5,10-Methylene-THF is an intermediate in the metabolism of Methane and the metabolism of Nitrogen. It is a substrate for Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (mitochondrial), Aminomethyltransferase (mitochondrial), Serine hydroxymethyltransferase (mitochondrial), Methylenetetrahydrofolate reductase, C-1-tetrahydrofolate synthase (cytoplasmic), Serine hydroxymethyltransferase (cytosolic) and Thymidylate synthase.