7a-Hydroxycholesterol

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7a-Hydroxycholesterol
2D structure for 7a-Hydroxycholesterol
Chemical Name	10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
Chemical Formula	C₂₇H₄₆O₂
CAS Number	Not Available
Chemical Information	HMDB01496
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Bile Acid Biosynthesis
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.18 +/- 0.047 umol/L Cerebrospinal Fluid (CSF): 0.004 +/- 0.0016 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Multiple Sclerosis Patients with advanced liver disease and biopsy-proven cirrhosis
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Patients with advanced liver disease and biopsy-proven cirrhosis): 0.054 +/- 0.019 umol/L Cerebrospinal Fluid (CSF) (Multiple Sclerosis): 0.005 +/- 0.0021 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
7alpha-hydroxycholesterol is an oxysterol, described as one biomarker for lipid peroxidation. (PMID: 17386651) Products of cholesterol oxidation accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery. (PMID: 17364953) 7alpha-hydroxycholesterol is acholesterol oxide that have been described as biomarker of oxidative stress in subjects with impaired glucose tolerance and diabetes. (PMID: 16634125)