Vanylglycol

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Vanylglycol
2D structure for Vanylglycol
Chemical Name	1-(4-hydroxy-3-methoxy-phenyl)ethane-1,2-diol
Chemical Formula	C₉H₁₂O₄
CAS Number	534-82-7
Chemical Information	HMDB01490
Biochemical Taxonomy	Alcohols and Polyols
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Central Nervous System Hypothalamus Platelet Brain
Normal Biofluid Concentrations	Blood: 0.0173 +/- 0.0034 uM Blood: 0.025 +/- 0.005 uM Cerebrospinal Fluid (CSF): 0.010 +/- 0.003 uM Cerebrospinal Fluid (CSF): 0.036 +/- 0.008 uM Cerebrospinal Fluid (CSF): 0.039 (0.047-0.081) uM Cerebrospinal Fluid (CSF): 0.042 +/- 0.005 uM Cerebrospinal Fluid (CSF): 0.044 +/- 0.020 uM Cerebrospinal Fluid (CSF): 0.05 (0.0058-0.094) uM Cerebrospinal Fluid (CSF): 0.05 +/- 0.032 uM Cerebrospinal Fluid (CSF): 0.050 (0.039-0.061) uM Cerebrospinal Fluid (CSF): 0.054 +/- 0.014 uM Cerebrospinal Fluid (CSF): 0.057 +/- 0.04 uM Cerebrospinal Fluid (CSF): 0.066 +/- 0.038 uM Cerebrospinal Fluid (CSF): 0.07 +/- 0.040 uM Cerebrospinal Fluid (CSF): 0.075 +/- 0.037 uM Cerebrospinal Fluid (CSF): 0.082 (0.051-0.11) uM Cerebrospinal Fluid (CSF): 0.116 +/- 0.16 uM Cerebrospinal Fluid (CSF): 0.17 +/- 0.095 umol/L
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Aromatic L-Amino Acid Decarboxylase (AADC) deficiency Cognitive Disorders Epilepsy not treated with phenytoin Epilepsy treated with phenytoin (Intoxicated) Epilepsy treated with phenytoin (after Intoxication) Epilepsy treated with phenytoin (well controlled) Epilepsy with cerebellar and cerebral atrophy Epilepsy with cerebellar atrophy Epilepsy with low thiamine Friedrich's Ataxia Hypothyroidism Major depression Mild vascular dementia Olivopontocerebral Atrophy Panic Disorder Schizophrenia Schizophrenia (Men) Schizophrenic patients Schizophrenic patients after treatment with ETC Severe vascular dementia Spastic Ataxia Subarachnoid Haemorrhage Vascular Dementia hypothyroidism
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Schizophrenia (Men)): 0.0237 +/- 0.011 uM Blood (Schizophrenia): 0.0232 +/- 0.0063 uM Cerebrospinal Fluid (CSF) (Aromatic L-Amino Acid Decarboxylase (AADC) deficiency): < 0.005 uM Cerebrospinal Fluid (CSF) (Cognitive Disorders): 0.012 uM Cerebrospinal Fluid (CSF) (Epilepsy not treated with phenytoin): 0.051 +/- 0.0054 uM Cerebrospinal Fluid (CSF) (Epilepsy treated with phenytoin (Intoxicated)): 0.05 +/- 0.018 uM Cerebrospinal Fluid (CSF) (Epilepsy treated with phenytoin (after Intoxication)): 0.064 +/- 0.045 uM Cerebrospinal Fluid (CSF) (Epilepsy treated with phenytoin (well controlled)): 0.048 +/- 0.033 uM Cerebrospinal Fluid (CSF) (Epilepsy with cerebellar and cerebral atrophy): 0.046 +/- 0.029 uM Cerebrospinal Fluid (CSF) (Epilepsy with cerebellar atrophy): 0.045 +/- 0.026 uM Cerebrospinal Fluid (CSF) (Epilepsy with low thiamine): 0.041 +/- 0.023 umol/L Cerebrospinal Fluid (CSF) (Friedrich's Ataxia): 0.042 +/- 0.0022 uM Cerebrospinal Fluid (CSF) (Hypothyroidism): 0.000031 +/- 0.000008 uM Cerebrospinal Fluid (CSF) (Major depression): 0.09 +/- 0.09 uM Cerebrospinal Fluid (CSF) (Mild vascular dementia): 0.039 (0.027-0.051) uM Cerebrospinal Fluid (CSF) (Olivopontocerebral Atrophy): 0.042 +/- 0.002 uM Cerebrospinal Fluid (CSF) (Panic Disorder): 0.037 +/- 0.006 uM Cerebrospinal Fluid (CSF) (Schizophrenic patients after treatment with ETC): 0.04 +/- 0.002 uM Cerebrospinal Fluid (CSF) (Schizophrenic patients): 0.05 +/- 0.002 uM Cerebrospinal Fluid (CSF) (Severe vascular dementia): 0.048 (0.035-0.061) uM Cerebrospinal Fluid (CSF) (Spastic Ataxia): 0.036 +/- 0.005 uM Cerebrospinal Fluid (CSF) (Subarachnoid Haemorrhage): 0 uM Cerebrospinal Fluid (CSF) (Vascular Dementia): 0.044 (0.032-0.056) uM Cerebrospinal Fluid (CSF) (Vascular Dementia): 0.044 (0.035-0.053) uM Cerebrospinal Fluid (CSF) (hypothyroidism): 0.00004 +/- 0.000005 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Vanylglycol (MHPG) is a O-methylated metabolite of normetanephrine. MHPG is formed by catechol-O-methyltransferase (COMT) from norepinephrine. Catecholamines play an important role in platelet activation and aggregation, epinephrine being the most potent one. Catecholamines are substantially increased during stress, exercise or smoking and could result in clinically important platelet activation if their action was not rapidly regulated. MHPG is found normally in urine, in plasma and cerebrospinal fluid. Alcohol consumption increases the level of HMPG in urine and CSF. Alcohol dehydrogenase has been shown to act on norepinephrine and produce HMPG. (PMID: 11958479, 9706478, 7735466, 2455302)