S-Adenosylmethionine

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S-Adenosylmethionine
2D structure for S-Adenosylmethionine
Chemical Name	(3-amino-3-carboxy-propyl)-[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl]-methyl-sulfanium
Chemical Formula	C₁₅H₂₃N₆O₅S
CAS Number	29908-03-0
Chemical Information	HMDB01185
Biochemical Taxonomy	Nucleosides
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Glycerophospholipid Metabolism Glycine, Serine and Threonine Metabolism Lysine Degradation Methionine Metabolism Nicotinate and Nicotinamide Metabolism Ubiquinone Biosynthesis
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Eye Lens Fibroblasts Gonads Intestine Kidney Muscle Myelin Placenta Skeletal Muscle Testis Epidermis
Normal Biofluid Concentrations	Blood: 2.2 +/- 0.38 uM Cerebrospinal Fluid (CSF): 0.25 (0.14 - 0.38) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Diabetic Ketosis Patients with neurodegenerative diseases
Other (Monogenic Disorders)	Adenomatous polyposis of the colon OMIM: 175100
Abnormal Biofluid Concentrations	Blood (Patients with neurodegenerative diseases): 0.11 (0.087-0.17) umol/L Urine (Diabetic Ketosis): 28.4 (25.3-31.6) umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)