Prostaglandin F2a

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Prostaglandin F2a
2D structure for Prostaglandin F2a
Chemical Name	7-[(1R,2S,3R,5R)-3,5-dihydroxy-2-[(3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
Chemical Formula	C₂₀H₃₄O₅
CAS Number	551-11-1
Chemical Information	HMDB01139
Biochemical Taxonomy	Prostanoids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Prostaglandin and Leukotriene Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Adrenal Gland Epidermis Placenta Platelet Testes Testis Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.084 (0.0-0.16) umol/L Cerebrospinal Fluid (CSF): 0.002 (0.0-0.004) uM Urine: 0.0000924 (0.0000588-0.000126) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Resuscitated patients
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Resuscitated patients): 1.0 +/- 0.17 umol/L
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Prostaglandin F2a (PGF2) is one of the earliest discovered and most common prostaglandins, is actively biosynthesized in various organs of mammals and exhibits a variety of biological activities, including contraction of pulmonary arteries. PGF2 is mainly synthesized directly from PGH2 by PGH2 9,11-endoperoxide reductase. A small amount of PGF2 is also produced from PGE2 by PGE2 9-ketoreductase. A PGF2 epimer has been reported to exhibit various biological activities, and its levels are increased in bronchoalveolar lavage fluid, plasma, and urine in patients with mastocytosis and bronchial asthma. PGF2 is synthesized from PGD2 by PGD2 11-ketoreductase. (PMID: 16475787)