L-Kynurenine

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L-Kynurenine
2D structure for L-Kynurenine
Chemical Name	2-amino-4-(2-aminophenyl)-4-oxo-butanoic acid
Chemical Formula	C₁₀H₁₂N₂O₃
CAS Number	343-65-7
Chemical Information	HMDB00684
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Central Nervous System Epidermis Fibroblasts Intestine Liver Neurons Placenta Spleen Brain
Normal Biofluid Concentrations	Blood: 1.35 (0.7-3.0) umol/L Blood: 2.4 +/- 0.49 uM Cerebrospinal Fluid (CSF): 0.052 +/- 0.0031 uM Cerebrospinal Fluid (CSF): 0.054 +/- 0.007 uM Urine: 2.85 +/- 1.94 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	CNS Infections CNS Tumors Hydrocephalus Intraventricular Hemorrhage
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (CNS Infections): 2.6 +/- 1.06 uM Cerebrospinal Fluid (CSF) (CNS Tumors): 1.6 +/- 0.58 uM Cerebrospinal Fluid (CSF) (Hydrocephalus): 0.18 +/- 0.040 uM Cerebrospinal Fluid (CSF) (Intraventricular Hemorrhage): 0.25 +/- 0.12 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Kynurenine is a metabolite of the amino acid tryptophan used in the production of niacin. L-kynurenine is a central compound of the pathway of tryptophan metabolism pathway since it can change to the neuroprotective agent kynurenic acid or to the neurotoxic agent quinolinic acid. The break-up of these endogenous compounds' balance can be observable in many disorders. It can occur in neurodegenerative disorders, such as Parkinson's disease, Huntington's and Alzheimer's disease, in stroke, in epilepsy, in multiple sclerosis, in amyotrophic lateral sclerosis, and in mental failures, such as schizophrenia and depression.