17-Hydroxyprogesterone

From NuGOwiki

(Redirected from HMDB00374)

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

17-Hydroxyprogesterone
2D structure for 17-Hydroxyprogesterone
Chemical Name	17-hydroxy-Pregn-4-ene-3,20-dione
Chemical Formula	C₂₁H₃₀O₃
CAS Number	68-96-2
Chemical Information	HMDB00374
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	C21-Steroid Hormone Metabolism
Biofluid Location	Blood Saliva
Tissue Location	Adrenal Cortex Adrenal Gland Testes Testis Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.011 (0.0003-0.023) uM Saliva: <1.00 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Phenylketonuria
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Phenylketonuria): 0.152 (0.0022- 0.302) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
It serves as an intermediate in the biosynthesis of hydrocortisone and gonadal steroid hormones. It is derived from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase. 17-Hydroxyprogesterone is a natural progestin and in pregnancy increases in the third trimester primarily due to fetal adrenal production. This hormone is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Normal levels are 3-90 ng/dl in children, and in women, 15-70 ng/dl prior to ovulation, and 35-290 ng/dl during the luteal phase. Measurements of levels of 17-hydroxyprogesterone are useful in the evaluation of patients with suspected congenital adrenal hyperplasia as the typical enzymes that are defective, namely 21-hydroxylase and 11β-hydroxylase, lead to a build-up of 17OHP. In contrast, the rare patient with 17α-hydroxylase deficiency will have very low or undetectable levels of 17OHP. 17OHP levels can also be used to measure contribution of progestational activity of the corpus luteum during pregnancy as progesterone but not 17OHP is also contributed by the placenta.