Tyramine

From NuGOwiki

(Redirected from HMDB00306)

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

Tyramine
2D structure for Tyramine
Chemical Name	4-(2-aminoethyl)phenol
Chemical Formula	C₈H₁₁NO
CAS Number	51-67-2
Chemical Information	HMDB00306
Biochemical Taxonomy	Catecholamines and Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Tyrosine Metabolism
Biofluid Location	Blood Urine
Tissue Location	Adrenal Medulla Brain Fibroblasts Intestine Liver Nerves Placenta Platelet Spleen Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.0095+/- 0.0021 uM Urine: 0.237 (0.2-0.275) umol/mmol creatinine Urine: 0.38 (0.23-0.78) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Trimethylaminuria OMIM: 602079
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
Tyramine is a monoamine compound derived from the amino acid tyrosine. Tyramine is metabolized by the enzyme monoamine oxidase. In foods, it is often produced by the decarboxylation of tyrosine during fermentation or decay. Foods containing considerable amounts of tyramine include fish, chocolate, alcoholic beverages, cheese, soy sauce, sauerkraut, and processed meat. A large dietary intake of tyramine can cause an increase in systolic blood pressure of 30 mmHg or more. Tyramine acts as a neurotransmitter via a G protein-coupled receptor with high affinity for tyramine called TA1. The TA1 receptor is found in the brain as well as peripheral tissues including the kidney. An indirect sympathomimetic, Tyramine can also serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals.