Uridine 5'-diphosphate

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Uridine 5'-diphosphate
2D structure for Uridine 5'-diphosphate
Chemical Name	Uridine 5'-(trihydrogen diphosphate)
Chemical Formula	C₉H₁₄N₂O₁₂P₂
CAS Number	58-98-0
Chemical Information	HMDB00295
Biochemical Taxonomy	Nucleotides
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Pyrimidine Metabolism
Biofluid Location	Blood
Tissue Location	Thyroid Gland Placenta
Normal Biofluid Concentrations	Blood: 41.0 +/- 12.0 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

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A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. UDP is an important extracellular pyrimidine signaling molecule that mediates diverse biological effects via P1 and P2 purinergic receptors, such as the uptake of thymidine and proliferation of gliomas. (PMID: 14558596) UDP induces intracellular Ca(2+) responses and oscillations in HeLa cells, due to the activation of P2Ys (G-protein coupled ATP receptors). (PMID: 1257952)