Sphingosine 1-phosphate

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Sphingosine 1-phosphate
2D structure for Sphingosine 1-phosphate
Chemical Name	(2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid
Chemical Formula	C₁₈H₃₈NO₅P
CAS Number	26993-30-6
Chemical Information	HMDB00277
Biochemical Taxonomy	Amino Alcohols
Functional Taxonomy	Second Messenger
Nutritional Taxonomy	Not Available
Metabolic Pathways	Glycerolipid Metabolism Glycerophospholipid Metabolism Glycosphingolipid Metabolism
Biofluid Location	Blood
Tissue Location	Platelet Fibroblasts
Normal Biofluid Concentrations	Blood: 0.044 +/- 0.001 umol/L
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Sphingosine 1-phosphate (S1P) is a phosphorylated sphingolipid metabolite with potent bioactive actions in the Sphingolipid metabolism, Calcium signaling pathway and Neuroactive ligand-receptor interaction. Generated by sphingosine kinases and ceramide kinase, S1P control numerous aspects of cell physiology, including cell survival and mammalian inflammatory responses. S1P is involved in cyclooxygenase-2 induction (COX-2), and regulate production of eicosanoids (important inflammatory mediators). S1P functions mainly via G-protein-coupled receptors and probably also has intracellular targets. (PMID 16219683)