Sphinganine

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Sphinganine
2D structure for Sphinganine
Chemical Name	(2S,3R)-2-amino-1,3-Octadecanediol
Chemical Formula	C₁₈H₃₉NO₂
CAS Number	764-22-7
Chemical Information	HMDB00269
Biochemical Taxonomy	Amino Alcohols
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Glycerolipid Metabolism Glycerophospholipid Metabolism Glycosphingolipid Metabolism
Biofluid Location	Blood
Tissue Location	Intestine Kidney Liver Platelet Spleen Stratum Corneum Thyroid Gland Fibroblasts
Normal Biofluid Concentrations	Blood: 0.011 +/- 0.00033 umol/L
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Sphinganine is a blocker postlysosomal cholesterol transport by inhibition of low-density lipoprotein-induced esterification of cholesterol and cause unesterified cholesterol to accumulate in perinuclear vesicles. It has been suggested the possibility that endogenous sphinganine may inhibit cholesterol transport in Niemann-Pick Type C (NPC) disease. (PMID 1817037)