Liothyronine

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Liothyronine
2D structure for Liothyronine
Chemical Name	2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propanoic acid
Chemical Formula	C₁₅H₁₂I₃NO₄
CAS Number	6893-02-3
Chemical Information	HMDB00265
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Pantothenate and CoA Biosynthesis Valine, Leucine and Isoleucine Biosynthesis Valine, Leucine and Isoleucine Degradation
Biofluid Location	Blood Saliva
Tissue Location	Adrenal Gland Epidermis Fibroblasts Intestine Nerves Neurons Placenta Platelet Skeletal Muscle Testes Thyroid Gland Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.000006 +/- 0.0000015 uM Blood: 0.00002 (0.0000015-0.000038) umol/L Saliva: 0.0 - 1.0 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Adolescent girls with anorexia nervosa
Other (Monogenic Disorders)	Thyroid hormone resistance, generalized, autosomal dominant OMIM: 188570
Abnormal Biofluid Concentrations	Blood (Adolescent girls with anorexia nervosa): 0.0000046 +/- 0.0000015 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx, I(-), and Cl(-). (Sax's Dangerous Properties of Industrial Materials)