Sorbitol

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Sorbitol
2D structure for Sorbitol
Chemical Name	(2R,3R,4R,5S)-1,2,3,4,5,6-hexanol
Chemical Formula	C₆H₁₄O₆
CAS Number	50-70-4
Chemical Information	HMDB00247
Biochemical Taxonomy	Alcohols and Polyols
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Aminosugars Metabolism Fructose and Mannose Metabolism Galactose Metabolism Glycerolipid Metabolism Glycolysis Glycosphingolipid Metabolism Pentose and Glucuronate Interconversions Pyruvate Metabolism Starch and Sucrose Metabolism Streptomycin Biosynthesis
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Saliva
Tissue Location	Adrenal Medulla Bladder Erythrocyte Eye Lens Fibroblasts Kidney Lens Liver Nerve Nerves Neurons Placenta Platelet Red Blood Cells Retina Sciatic Nerve Adipose Tissue
Normal Biofluid Concentrations	Blood: 1.10 (0.72-1.47) uM Blood: 13.0 (4.0-24.0) uM Cerebrospinal Fluid (CSF): 13.0 (9.49-16.5) uM Cerebrospinal Fluid (CSF): 15.6 +/- 1.9 uM Cerebrospinal Fluid (CSF): 17.2 +/- 4.6 uM Cerebrospinal Fluid (CSF): 19.4 +/- 5.6 uM Cerebrospinal Fluid (CSF): 19.43 +/- 5.65 uM Saliva: <1.00 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Alzheimer Alzheimer's disease
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Alzheimer's disease): 22.89 +/- 3.34 uM Cerebrospinal Fluid (CSF) (Alzheimer): 23.3 +/-3.3 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications. Ascorbic acid fermentation; in solution form for moisture-conditioning of cosmetic creams and lotions, toothpaste, tobacco, gelatin; bodying agent for paper, textiles, and liquid pharmaceuticals; softener for candy; sugar crystallization inhibitor; surfactants; urethane resins and rigid foams; plasticizer, stabilizer for vinyl resins; food additive (sweetener, humectant, emulsifier, thickener, anticaking agent); dietary supplement. (Hawley's Condensed Chemical Dictionary) Biological Source: Occurs widely in plants ranging from algae to the higher orders. Fruits of the plant family Rosaceae, which include apples, pears, cherries, apricots, contain appreciable amounts. Rich sources are the fruits of the Sorbus and Crataegus spp. Use/Importance: Used for manuf. of sorbose, propylene glycol, ascorbic acid, resins, plasticizers and as antifreeze mixtures with glycerol or glycol. Tablet diluent, sweetening agent and humectant, other food uses. Used in photometric determination of Ru(VI) and Ru(VIII); in acid-base titration of borate (Dictionary of Organic Compounds)