Pyruvic acid

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Pyruvic acid
2D structure for Pyruvic acid
Chemical Name	2-oxopropanoic acid
Chemical Formula	C₃H₄O₃
CAS Number	127-17-3
Chemical Information	HMDB00243
Biochemical Taxonomy	Keto-Acids
Functional Taxonomy	Antioxidant Energy Supplier
Nutritional Taxonomy	Not Available
Metabolic Pathways	Alanine and Aspartate Metabolism Arginine and D-Ornithine Metabolism Butanoate Metabolism Glycolysis Methionine Metabolism Propanoate Metabolism Purine Metabolism Pyruvate Metabolism Valine, Leucine and Isoleucine Biosynthesis
Biofluid Location	Blood Cellular Cytoplasm Cerebrospinal Fluid (CSF) Saliva Urine
Tissue Location	Brain Fibroblasts Kidney Liver Muscle Myocardium Neurons Pancreas Skeletal Muscle Spleen Testis Thyroid Gland Adipose Tissue
Normal Biofluid Concentrations	Blood: 140.0 (22.0-258.0) uM Blood: 55.0 (39.0-71.0) uM Blood: 63.0 +/- 25.0 uM Blood: 75.5 (10.0-141.0) uM Blood: 76.0 +/- 10.0 uM Blood: 81.0 +/- 34.0 uM Cellular Cytoplasm: 360 (350-370) uM Cellular Cytoplasm: 77.0 (27.0-127) uM Cerebrospinal Fluid (CSF): 115.0 +/- 17.0 uM Cerebrospinal Fluid (CSF): 136.0 +/- 29.0 uM Cerebrospinal Fluid (CSF): 153.0 (121.0-185.0) uM Cerebrospinal Fluid (CSF): 53 +/- 42 uM Cerebrospinal Fluid (CSF): 71.0 +/- 31.0 uM Saliva: 5350 (100-10600) uM Urine: 1.7985 (0-3.597) umol/mmol creatinine Urine: 10.2 (4.7-40.5) umol/mmol creatinine Urine: 12.4 (5.3-22.1) umol/mmol creatinine Urine: 21.2 (8.8-59.3) umol/mmol creatinine Urine: 28.6 (12.9-43.0) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Anoxia Bacterial meningitis Patients with genetic metabolic abnormamalities
Other (Monogenic Disorders)	Adenosine triphosphate, elevated, of erythrocytes OMIM: 102900 Pyruvate decarboxylase deficiency OMIM: 312170 Pyruvate kinase deficiency of red cells OMIM: 266200 Tyrosinemia, type III OMIM: 276710
Abnormal Biofluid Concentrations	Cellular Cytoplasm (Anoxia): 140 (130-150) uM Cerebrospinal Fluid (CSF) (Bacterial meningitis): 195.0 (175.0-215.0) uM Urine (Patients with genetic metabolic abnormamalities): 9.79 +/- 9.34 umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed.) Biological Source: Intermediate in primary metabolism including fermentation processes. Present in muscle in redox equilibrium with Lactic acid. A common constituent, as a chiral cyclic acetal linked to saccharide residues, of bacterial polysaccharides. Isolated from cane sugar fermentation broth and peppermint. Constituent of Bauhinia purpurea, Cicer arietinum (chickpea), Delonix regia, Pisum sativum (pea) and Trigonella caerulea (sweet trefoil) Use/Importance: Reagent for regeneration of carbonyl compdounds from semicarbazones, phenylhydrazones and oximes. Flavoring ingredient (Dictionary of Organic Compounds)