Quinolinic acid

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Quinolinic acid
2D structure for Quinolinic acid
Chemical Name	2,3-Pyridinedicarboxylic acid
Chemical Formula	C₇H₅NO₄
CAS Number	89-00-9
Chemical Information	HMDB00232
Biochemical Taxonomy	Dicarboxylic Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Nicotinate and Nicotinamide Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Central Nervous System Neurons Spleen Brain
Normal Biofluid Concentrations	Blood: 0.47 +/- 0.047 umol/L Cerebrospinal Fluid (CSF): 0.018 (0.012-0.024) uM Cerebrospinal Fluid (CSF): 0.018 +/- 0.006 uM Cerebrospinal Fluid (CSF): 0.02 +/- 0.002 uM Cerebrospinal Fluid (CSF): 0.022 +/- 0.0021 uM Cerebrospinal Fluid (CSF): 0.023 +/- 0.002 uM Cerebrospinal Fluid (CSF): 0.07 (0.05-0.10) uM Cerebrospinal Fluid (CSF): 0.07 (0.05-0.10) uM Urine: 10.5 umol/mmol creatinine Urine: 13.2 umol/mmol creatinine Urine: 2.5 +/- 1.1 umol/mmol creatinine Urine: 44.8 umol/mmol creatinine Urine: 44.8 umol/mmol creatinine Urine: 7.3 umol/mmol creatinine Urine: 7.7 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Anemia Brain oedema or injury CNS Infections CNS Tumors Cerebral malaria Convulsions HIV Hepatic coma (fatal) Hydrocephalus Intraventricular Hemorrhage Severe Malaria TB meningitis Uncomplicated malaria
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Anemia): 0.10 (0-2.37) uM Cerebrospinal Fluid (CSF) (Brain oedema or injury): 0.29 (0.17-0.41) uM Cerebrospinal Fluid (CSF) (CNS Infections): 1.08 +/- 0.54 uM Cerebrospinal Fluid (CSF) (CNS Tumors): 0.28 +/- 0.082 uM Cerebrospinal Fluid (CSF) (Cerebral malaria): 0.09 (0.07-0.11) uM Cerebrospinal Fluid (CSF) (Convulsions): 0.03 (0.01-0.13) uM Cerebrospinal Fluid (CSF) (HIV): 3.78 +/- 0.88 uM Cerebrospinal Fluid (CSF) (Hepatic coma (fatal)): 0.00015 (0.00011-0.00019) uM Cerebrospinal Fluid (CSF) (Hydrocephalus): 0.031 +/- 0.005 uM Cerebrospinal Fluid (CSF) (Intraventricular Hemorrhage): 0.2 +/- 0.113 uM Cerebrospinal Fluid (CSF) (Severe Malaria): 0.8 (0.7-1.0) uM Cerebrospinal Fluid (CSF) (TB meningitis): 6.10 (0.37-100.9) uM Cerebrospinal Fluid (CSF) (Uncomplicated malaria): 0.08 (0.04-0.16) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. Quinolinic acid (QUIN) is a product of tryptophan metabolism that can act as an endogenous brain excitotoxin when released by activated macrophages. (Valle et. al, Brain 127:1047 (2004))