O-Phosphoethanolamine

From NuGOwiki

(Redirected from HMDB00224)

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

O-Phosphoethanolamine
2D structure for O-Phosphoethanolamine
Chemical Name	2-aminoethyl dihydrogen phosphate
Chemical Formula	C₂H₈NO₄P
CAS Number	1071-23-4
Chemical Information	HMDB00224
Biochemical Taxonomy	Acyl Phosphates
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Glycerophospholipid Metabolism Glycosphingolipid Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 19 +/- 9.9 uM Blood: 4.0 +/- 2.0 uM Cerebrospinal Fluid (CSF): 6.0 +/- 1.1 uM Cerebrospinal Fluid (CSF): 6.30 (4.70-9.60) uM Urine: 4.276 (1.644-6.908) umol/mmol creatinine Urine: 8.2 +/- 2.0 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Severe traumatic brain injury (TBI)
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Severe traumatic brain injury (TBI)): 11.3 (6.50-16.4) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
Phosphoethanolamine (PE) is a phosphomonoester metabolite of the phospholipid metabolism. PE is a precursor of phospholipid synthesis and a product of phospholipid breakdown. Phosphomonoesters are present at much higher levels in brain than in other organs. In developing brain, phosphomonoesters are normally elevated during the period of neuritic proliferation. This also coincides with the occurrence of normal programmed cell death and synaptic pruning in developing brain. These findings are consistent with the role of phosphomonoesters in membrane biosynthesis. PE shows a strong structural similarity to the inhibitory neurotransmitter, GABA, and the GABAB receptor partial agonist, 3-amino-propylphosphonic acid. PE is a phosphomonoester which is decreased in post-mortem Alzheimer's disease (AD) brain. (PMID: 7791524, 8588821, 11566853)