Norepinephrine

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Norepinephrine
2D structure for Norepinephrine
Chemical Name	4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol
Chemical Formula	C₈H₁₁NO₃
CAS Number	51-41-2
Chemical Information	HMDB00216
Biochemical Taxonomy	Catecholamines and Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Tyrosine Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Adrenal Cortex Adrenal Gland Adrenal Medulla Bladder Brain Central Nervous System Epidermis Fibroblasts Gonads Heart Intestine Kidney Lymphocyte Muscle Nerves Neurons Pancreas Placenta Platelet Prostate Skeletal Muscle Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.0016 +/- 0.00012 uM Cerebrospinal Fluid (CSF): 0.0001 +/- 0.00002 uM Cerebrospinal Fluid (CSF): 0.0014 uM Cerebrospinal Fluid (CSF): 0.02 (0.0096-0.031) uM Urine: 0.0138 (0.0062-0.032) umol/mmol creatinine Urine: 0.0185 (0.00342-0.0336) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Exercise Heat stress Hypothyroidism Pheochromocytoma Subarachnoid haemorrhage hypothyroid patients
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Exercise): 0.0070 (0.0034-0.011) uM Blood (Heat stress): 0.001 +/- 0.0013 uM Blood (Pheochromocytoma): 0.004 +/- 0.022 umol/L Blood (Subarachnoid haemorrhage): 0.0037 +/- 0.00048 uM Cerebrospinal Fluid (CSF) (Hypothyroidism): 0.00005 (0.00003-0.00007) uM Cerebrospinal Fluid (CSF) (hypothyroid patients): 0.0001 +/- 0.00002 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.