Indoleacetic acid

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Indoleacetic acid
2D structure for Indoleacetic acid
Chemical Name	<nowiki>2-(1H-indol-3-yl)acetic acid</nowiki>
Chemical Formula	C<sub>10</sub>H<sub>9</sub>NO<sub>2</sub>
CAS Number	87-51-4
Chemical Information	HMDB00197
Biochemical Taxonomy	<p> Indoles and Indole Derivatives </p>
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	<p> Bile Acid Biosynthesis Butanoate Metabolism Fatty Acid Metabolism Glycerolipid Metabolism Glycolysis Lysine Degradation Propanoate Metabolism Pyruvate Metabolism Valine, Leucine and Isoleucine Degradation </p>
Biofluid Location	<p> Blood Cerebrospinal Fluid (CSF) Urine </p>
Tissue Location	<p> Central Nervous System Fibroblasts Hippocampus Hypothalamus Liver Platelet Spinal Cord Striatum Brain </p>
Normal Biofluid Concentrations	<p> Blood: 0.05 (0.0- 0.1) uM Blood: 0.05 (0.0-0.118) uM Cerebrospinal Fluid (CSF): 0.03 (0.005 - 0.3) uM Urine: 2.0 +/- 1.0 umol/mmol creatinine Urine: 2.8 umol/mmol creatinine Urine: 3.4 umol/mmol creatinine Urine: 3.8 umol/mmol creatinine Urine: 4.6 umol/mmol creatinine Urine: 5.2 umol/mmol creatinine Urine: 5.6 (5.5 - 5.8) umol/mmol creatinine </p>
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	<p> Acute Appendicitis Irritable bowel syndrome (IBS) Peritonitis </p>
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	<p> Urine (Acute Appendicitis): 3.1 +/- 0.14 umol/mmol creatinine Urine (Irritable bowel syndrome (IBS)): 3.0 (2.5-6.8) umol/mmol creatinine Urine (Peritonitis): 2.5 +/- 0.22 umol/mmol creatinine </p>
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines Indoleacetic acid (IAA) is a member of the group of phytohormones called auxins. IAA is generally considered to be the most important native auxin. Plant cells synthesize IAA from tryptophan. (wikipedia) IAA and some derivatives can be oxidised by horseradish peroxidase (HRP) to cytotoxic species. IAA is only toxic after oxidative decarboxylation; the effect of IAA/HRP is thought to be due in part to the formation IBS of methylene-oxindole, which may conjugate with DNA bases and protein thiols. IAA/HRP could be used as the basis for targeted cancer, a potential new role for plant auxins in cancer therapy. (PMID: 11163327)