Isocitric acid

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Isocitric acid
2D structure for Isocitric acid
Chemical Name	1-hydroxypropane-1,2,3-tricarboxylic acid
Chemical Formula	C₆H₈O₇
CAS Number	320-77-4
Chemical Information	HMDB00193
Biochemical Taxonomy	Hydroxy Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Glutathione Metabolism Glyoxylate and Dicarboxylate Metabolism Reductive Carboxylate Cycle (CO2 Fixation)
Biofluid Location	Blood Cellular Cytoplasm Cerebrospinal Fluid (CSF) Semen Urine
Tissue Location	Adrenal Gland
Normal Biofluid Concentrations	Blood: 6.0 (0.0-10.0) uM Cellular Cytoplasm: 38 (23-53) uM Cerebrospinal Fluid (CSF): 10.0 +/- 9.0 uM Semen: 400 - 1500 uM Urine: 120.1 umol/mmol creatinine Urine: 19.08 (5.26 - 42.76) umol/mmol creatinine Urine: 38.9 umol/mmol creatinine Urine: 45 umol/mmol creatinine Urine: 53.7 umol/mmol creatinine Urine: 94.3 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Anoxia
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cellular Cytoplasm (Anoxia): 15 (14.8-15.2) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
The citrate oxidation to isocitrate is catalyzed by the enzyme aconitase. Human prostatic secretion is remarkably rich in citric acid and low aconitase activity will therefore play a significant role in enabling accumulation of high citrate levels (PubMed ID 8115279)