L-Dopa

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L-Dopa
2D structure for L-Dopa
Chemical Name	2-amino-3-(3,4-dihydroxy-phenyl)-propionic acid
Chemical Formula	C₉H₁₁NO₄
CAS Number	59-92-7
Chemical Information	HMDB00181
Biochemical Taxonomy	Catecholamines and Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Tyrosine Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Bladder Brain Epidermis Intestine Muscle Nerves Neurons Placenta Platelet Striatum Adrenal Medulla
Normal Biofluid Concentrations	Blood: 0.00723 +/- 0.00097 uM Cerebrospinal Fluid (CSF): 0.0035 +/- 0.0009 uM Urine: 0.008 (0.0036-0.0138) umol/mmol creatinine Urine: 0.0136 +/- 0.0033 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Probable Alzheimer's Disease
Other (Monogenic Disorders)	Dystonia, dopa-responsive OMIM: 128230 Segawa syndrome, autosomal recessive OMIM: 605407
Abnormal Biofluid Concentrations	Blood (Probable Alzheimer's Disease): 14.0 +/- 2.53 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of Parkinsonian Disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.