L-Proline

From NuGOwiki

(Redirected from HMDB00162)

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

L-Proline
2D structure for L-Proline
Chemical Name	(2S)-pyrrolidine-2-carboxylic acid
Chemical Formula	C₅H₉NO₂
CAS Number	147-85-3
Chemical Information	HMDB00162
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Glycine, Serine and Threonine Metabolism Porphyrin and Chlorophyll Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Saliva Urine
Tissue Location	All Tissues
Normal Biofluid Concentrations	Blood: 168.0 (108.0-228.0) uM Blood: 168.0 +/- 49.0 uM Blood: 198.0 +/- 63.0 uM Blood: 230.0 +/- 75.0 uM Blood: 239.0 +/- 70.0 uM Cerebrospinal Fluid (CSF): 4.0 (0 - 8.0) uM Saliva: >10 uM Urine: 1.0 (0.5-2.0) umol/mmol creatinine Urine: 2.171 (0.0658-4.276) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Conventional hemodialysis (CHD) Nocturnal hemodialysis (NHD)
Other (Monogenic Disorders)	Hyperprolinemia, type I OMIM: 239500
Abnormal Biofluid Concentrations	Blood (Conventional hemodialysis (CHD)): 201.0 +/- 149.5 uM Blood (Nocturnal hemodialysis (NHD)): 227.2 +/- 108.4 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
L-Proline is one of the twenty amino acids which are used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. In biological terminology, however, the category "amino acids" is generally taken to include proline. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons.