Guanosine

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Guanosine
2D structure for Guanosine
Chemical Name	Guanosine
Chemical Formula	C₁₀H₁₃N₅O₅
CAS Number	118-00-3
Chemical Information	HMDB00133
Biochemical Taxonomy	Nucleosides
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Bile Acid Biosynthesis Fatty Acid Metabolism Fructose and Mannose Metabolism Galactose Metabolism Glycerolipid Metabolism Glycolysis Glycosphingolipid Metabolism Pentose and Glucuronate Interconversions Pyruvate Metabolism
Biofluid Location	Blood Cellular Cytoplasm Urine
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.258 +/- 0.174 uM Blood: 0.8 +/- 0.5 uM Blood: 4.5 +/- 2.9 uM Cellular Cytoplasm: 4.5 +/- 2.9 uM Urine: 0.13 (0.022-0.23) umol/mmol creatinine Urine: 490.0 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Purine-nucleoside phosphorylase (PNP; EC 2.4.2.1) deficiency.
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Urine (Purine-nucleoside phosphorylase (PNP; EC 2.4.2.1) deficiency.): 35.0 - 2588.0 umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a beta-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate) and GTP (guanosine triphosphate). (Wikipedia) The nucleoside guanosine exert important neuroprotective and neuromodulator roles in the central nervous system, which may be related to inhibition of the glutamatergic neurotransmission activity. Guanosine is the specific extracellular guanine-based purines effector and indicate that its conversion occurs not only in the central nervous system but also peripherally. (PMID: 16325434)