Dimethylglycine

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Dimethylglycine
2D structure for Dimethylglycine
Chemical Name	2-dimethylaminoacetic acid
Chemical Formula	C₄H₉NO₂
CAS Number	1118-68-9
Chemical Information	HMDB00092
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Methionine Metabolism
Biofluid Location	Blood Urine
Tissue Location	Kidney Liver
Normal Biofluid Concentrations	Blood: 1.9 (1.1-3.4) uM Blood: 2.6 (1.8-3.7) uM Urine: 3.4 (0.7-10.6) umol/mmol creatinine Urine: 6.2 (0.8-11.2) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Chronic Renal failure
Other (Monogenic Disorders)	Dimethylglycine dehydrogenase deficiency OMIM: 605850
Abnormal Biofluid Concentrations	Blood (Chronic Renal failure): 4.8 (3.6-6.2) umol/L
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. The human body produces DMG when metabolizing choline into Glycine. Dimethylglycine that is not metabolized in the liver is transported by the circulatory system to body tissue. Dimethylglycine was popular with Russian athletes and cosmonauts owing to its reputed ability to increase endurance and reduce fatigue. DMG is also a byproduct of homocysteine metabolism. Homocysteine and betaine are converted to methionine and N, N-dimethylglycine by betaine-homocysteine methyltransferase.