Dehydroepiandrosterone

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Dehydroepiandrosterone
2D structure for Dehydroepiandrosterone
Chemical Name	(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
Chemical Formula	C₁₉H₂₈O₂
CAS Number	53-43-0
Chemical Information	HMDB00077
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Androgen and Estrogen Metabolism C21-Steroid Hormone Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Saliva
Tissue Location	Adrenal Cortex Adrenal Gland Adrenal Glands Brain Epidermis Fibroblasts Gonads Kidneys Liver Muscle Neurons Placenta Platelet Prostate Testes Testis Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.001 (0.00034-0.0017) uM Blood: 0.0087 (0.0035-0.013) uM Blood: 0.023 (0.0045-0.042) uM Cerebrospinal Fluid (CSF): 0.00101 (0.00002-0.002) uM Saliva: 0.0033 (0.0024-0.0090) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Dehydroepiandrosterone (DHEA) is a natural steroid hormone produced from cholesterol by the adrenal glands. DHEA is also produced in the gonads, adipose tissue and the brain. DHEA is structurally similar to, and is a precursor of, androstenedione, testosterone, estradiol, estrone and estrogen. It is the most abundant hormone in the human body. Most of DHEA is sulfated (dehydroepiandrosterone sulfate- DEHAS) before secretion. DHEAS is the sulfated version of DHEA; - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS.