Dopamine

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Dopamine
2D structure for Dopamine
Chemical Name	4-(2-aminoethyl)benzene-1,2-diol
Chemical Formula	C₈H₁₁NO₂
CAS Number	62-31-7
Chemical Information	HMDB00073
Biochemical Taxonomy	Catecholamines and Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Alkaloid Biosynthesis I Tyrosine Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Adrenal Cortex Adrenal Gland Adrenal Medulla Bladder Brain Epidermis Fibroblasts Kidney Kidney (Adrenal Glands) Muscle Myelin Nerves Neuron Neurons Pancreas Placenta Platelet Skeletal Muscle Spleen Striatum Testes Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.00022 +/- 0.00020 uM Cerebrospinal Fluid (CSF): 0.002+/-0.002 uM Cerebrospinal Fluid (CSF): 0.0045 +/- 0.0026 uM Cerebrospinal Fluid (CSF): 0.0059 +/- 0.002 uM Urine: 0.10 (0.066-0.16) umol/mmol creatinine Urine: 0.107 (0.043-0.172) umol/mmol creatinine Urine: 0.22 +/- 0.07 umol/mmol creatinine Urine: 0.44 +/- 0.13 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Alzheimer's Disease Hypothyroidism Probable Alzheimer's Disease Vitiligo hypothyroid patients
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Probable Alzheimer's Disease): 18.02 +/- 2.45 uM Cerebrospinal Fluid (CSF) (Alzheimer's Disease): 0.000078 (0.0000065-0.00015) uM Cerebrospinal Fluid (CSF) (Hypothyroidism): 0.000021 (0.000015-0.000027) uM Cerebrospinal Fluid (CSF) (hypothyroid patients): 0.00002 +/- 0.000006 uM Urine (Vitiligo): 0.37 +/- 0.03 umol/mmol creatinine Urine (Vitiligo): 0.4 +/- 0.05 umol/mmol creatinine Urine (Vitiligo): 0.49 +/- 0.06 umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Dopamine is a member of the catecholamine (Neurotransmitters) family in the brain, and is a precursor to epinephrine (adrenaline) and norepinephrine (noradrenaline). Dopamine is synthesized in the body (mainly by nervous tissue and adrenal glands) first by the hydration of the amino acid tyrosine to DOPA by tyrosine hydroxylase and then by the decarboxylation of DOPA by aromatic-L-amino-acid decarboxylase. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (Dopamine receptors) mediates its action. --PubChem