Cortisol

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Cortisol
2D structure for Cortisol
Chemical Name	11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Chemical Formula	C₂₁H₃₀O₅
CAS Number	50-23-7
Chemical Information	HMDB00063
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Androgen and Estrogen Metabolism C21-Steroid Hormone Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Saliva Urine
Tissue Location	Adrenal Cortex Adrenal Gland Adrenal Medulla Bladder Brain Fetus Fibroblasts Gonads Gut Intestine Kidney Liver Lymphocyte Muscle Nerves Neurons Pancreas Placenta Platelet Prostate Skeletal Muscle Skin Spleen Testes Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.199 (0.058-0.475) uM Blood: 0.255 (0.066-0.443) uM Blood: 0.282 (0.073-0.491) uM Blood: 0.313 (0.081-0.545) uM Blood: 0.32 +/- 0.19 uM Blood: 0.348 (0.090-0.605) uM Blood: 0.359 (0.130-0.519) uM Blood: 0.386 (0.100-0.671) uM Blood: 0.427 (0.110-0.744) uM Blood: 0.46 +/- 0.30 umol/L Cerebrospinal Fluid (CSF): 0.02 +/- 0.011 uM Cerebrospinal Fluid (CSF): 0.052 +/- 0.023 uM Saliva: 2.35 uM Urine: 1.77 (1.28-2.27) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Functional Hypothalamic Amenorrhea (FHA) female Major affective disorder Normal after treatment with Ketoconazole Patients with Tic disorder Stress period
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Major affective disorder): 0.27 +/- 0.06 uM Blood (Patients with Tic disorder): 0.41 +/- 0.2 umol/L Cerebrospinal Fluid (CSF) (Functional Hypothalamic Amenorrhea (FHA) female): 0.0001+/- 0.00001 uM Cerebrospinal Fluid (CSF) (Normal after treatment with Ketoconazole): 0.03 +/- 0.005 uM Saliva (Stress period): 8.69 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.; As an oral or injectable drug, cortisol is also known as hydrocortisone. It is used as an immunosuppressive drug, given by injection in the treatment what is cellulite of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis.; Cortisol or Hydrocortisone is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress. It increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Its synthetic counterpart (hydrocortisone) is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortisol is synthesized from pregnenolone. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning, and lower levels in the evening, several hours after the onset of sleep.; Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation.