Cyclic AMP

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Cyclic AMP
2D structure for Cyclic AMP
Chemical Name	cyclic 3',5'-(hydrogen phosphate)Adenosine
Chemical Formula	C₁₀H₁₂N₅O₆P
CAS Number	60-92-4
Chemical Information	HMDB00058
Biochemical Taxonomy	Nucleotides
Functional Taxonomy	Second Messenger
Nutritional Taxonomy	Not Available
Metabolic Pathways	Purine Metabolism
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	All Tissues
Normal Biofluid Concentrations	Blood: 0.0085 +/- 0.0005 umol/L Cerebrospinal Fluid (CSF): 0.020 (0.016-0.024) uM Cerebrospinal Fluid (CSF): 0.020 +/- 0.004 uM Cerebrospinal Fluid (CSF): 0.020+/- 0.004 uM Cerebrospinal Fluid (CSF): 0.021 +/- 0.008 uM Cerebrospinal Fluid (CSF): 0.024 (0.022-0.026) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Hypoxic-ischemic encephalopathy Idiopathic polyneuritis Patients with sildenafil-induced headache Serous meningitis serious meningitis
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Patients with sildenafil-induced headache): 0.0077 +/- 0.0003 umol/L Cerebrospinal Fluid (CSF) (Hypoxic-ischemic encephalopathy): 0.00860 (0.00620-0.0110) uM Cerebrospinal Fluid (CSF) (Hypoxic-ischemic encephalopathy): 0.014 (0.012-0.017) uM Cerebrospinal Fluid (CSF) (Idiopathic polyneuritis): 0.011 (0.0082-0.014) uM Cerebrospinal Fluid (CSF) (Idiopathic polyneuritis): 0.0110 +/- 0.0028 uM Cerebrospinal Fluid (CSF) (Serous meningitis): 0.034 (0.021-0.046) uM Cerebrospinal Fluid (CSF) (serious meningitis): 0.033 +/- 0.012 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Cyclic AMP is an adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH. cAMP is synthesized from ATP by adenylate cyclase. Adenylate cyclase is located at the cell membranes. Adenylate cyclase is activated by the hormones glucagon and adrenaline and by G protein. Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline. cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase.